TECHNOLOGY
The Galactis™ Screening System
About Biologics Optimization
Being able to generate a great variety of products, BiolActis has put in place a High Throughput Screening System called Galactis™. The Galactis™ system is a unique metabonomics tool allowing a swift and efficient screening of health benefits of various products generated by the Valactis™ production technology. The approach originates from the pharmaceutical industry and consists in using various analytical technologies such as NMR and Mass spectroscopy combined with genomics and proteomics. These equipments enable the testing of 96,000 different genes and proteins grouped by metabolic and signal transduction pathways combined to animal models. In addition, when a hit is identified, the product is compared to a well-established drug in the market allowing a benchmarking analysis. The system also permits iterations that will lead to optimization of the Biologics for a specific application.
A Versatile Technology
Galactis™ is coupled to in vitro and animal disease models that can be used to analyze complex biological mixtures, probiotics, proteins/peptides, vitamins, antioxydants, minerals, growth factors, hormones, cyto- and chemokine. In addition to the use of several pathology models for each product, Galactis™ also uses healthy animals in order to validate safety and in vitro analysis in order to elucidate their mechanisms of action. The following pathways are grouped on the screening Platform:
- Cancer (breast, prostate, colon, pancreatic, lung)
- Obesity, metabolic syndrome, diabetes, hypertension
- Atherosclerosis, Cardiovascular disease, Lipidemia
- Inflammation/pain
- Safety (Absorption, Distribution, Metabolism, Excretion)
- Angiogenesis
- Cell growth
- Inflammatory diseases (Arthritis/MS/psoriasis/restenosis)
- Auto-immunity/Allergies/Asthma
- Liver disorder
- Oxydo-reduction pathways
The Galactis™ Screening System
| In Vitro | In Vivo | In Silico |
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| CELL CULTURE SYSTEMS (Primary and Immortalized) |
RATS AND MICE MODELS | BIOANALYSIS |
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